PRODUCTS

TCR-T Cell Therapy

Pipeline

No.
Target
Indications
TCR cloning
Affinity Optimization
Pre-clinical
Clinical Trial
CRTE7A2
Target
HPV16 E7
Indication
Cervical Cancer,Head and Neck Cancer
 

IIT & IND in H1 2023   

TCR Cloning
 
Optimization
 
Pre-clinical
 
Clinical Trial
 

IIT & IND in H1 2023   

  • Target

    CRTE7A2-01 treatment for HPV-positive people

  • Development Stage

    The pioneering TCR-T cell therapy in China to treat advanced HPV16 positive cervical cancer, anal cancer, and head and neck cancer

  • Cervical cancer caused by HPV

    The HPV infection rate among women in China reached 21.1%, and as a result, there are 110,000 new cases of cervical cancer per year and 60,000 deaths

  • Limited HPV vaccine coverage

    Nearly 40% of women in China cannot vaccinate because of HPV positive or being overage

  • HPV TCR-T has significant efficacy

    HPV TCR-T is effective in the treatment of HPV-positive cervical cancer, head and neck squamous cell carcinoma, 6/12 cases showed significant shrinkage

CRTM1A2
Target
MAGE A1
Indication
Multiple Solid tumors
 

IIT in H1 2023

TCR Cloning
 
Optimization
 
Pre-clinical
 
Clinical Trial
 

IIT in H1 2023

  • Target

  • Development Stage

CRTKVA11
Target
KRAS G12V
Indication
Colorectal & Pancreatic Cancer
 

IIT in H1 2022

TCR Cloning
 
Optimization
 
Pre-clinical
 
Clinical Trial
 

IIT in H1 2022

  • Target

    TCR-T CRTKVA11-01 treatment for people with KRAS mutation

  • Development Stage

    Globally innovative TCR-T cell therapy for treating advanced solid tumors with KRAS G12V mutation

  • KRAS is a Oncogenic driver mutation for multiple tumors

    KRAS is one of the most common mutations in solid tumors, and is present in about 90% pancreatic cancer, 40% colorectal cancer, and 30% lung adenocarcinoma

  • KRAS-inhibitors are prone to resistance

    G12C inhibitors have a short duration of efficacy, and there are no available candidate drugs for G12D and G12V.

  • KRAS TCR-T has significant efficacy

    Case reports of KRAS TCR-T therapy can completely clear metastases and maintain 4 years of disease-free survival (DFS)

CRTKDA11
Target
KRAS G12D
Indication
Colorectal & Pancreatic Cancer
 

TCR Cloning
 
Optimization
 
Pre-clinical
 
Clinical Trial
 

  • Target

    TCR-T CRTKVA11-01 treatment for people with KRAS mutation

  • Development Stage

    Globally innovative TCR-T cell therapy for treating advanced solid tumors with KRAS G12D mutation

  • KRAS is a Oncogenic driver mutation for multiple tumors

    KRAS is one of the most common mutations in solid tumors, and is present in about 90% pancreatic cancer, 40% colorectal cancer, and 30% lung adenocarcinoma

  • KRAS-inhibitors are prone to resistance

    G12C inhibitors have a short duration of efficacy, and there are no available candidate drugs for G12D and G12V.

  • KRAS TCR-T has significant efficacy

    Case reports of KRAS TCR-T therapy can completely clear metastases and maintain 4 years of disease-free survival (DFS)

Tumor indications covered by our early TCR-T products

Antigen targets
under development
Covered HLA genotypes
China Han
Caucasian
Covered HLA genotypes
China Han
Caucasian

Product Advantages

TCR-T Cell Therapy
  • Strong targeting capability that covers intracellular antigens, and 90% of cellular proteins can be used as targets
  • TCR-T has better homing to solid tumor
  • The excellent efficacy in solid tumors has been supported by multiple clinical trials
  • Natural TCR signal with high sensitivity, slight CRS response and high safety